Capital International Investors
· Reduced
Change
−1.7M
Date
Q1 2026
SY
| Investor | Type | Est. change | Change | Δ Own | Date | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Capital International Investors
· Reduced
Change
−1.7M
Date
Q1 2026
|
Capital International Investors | Reduced· Q1 2026 | – | −1.7M | – | Q1 2026 | |||||
|
JPMorgan Chase & Co
· Added
Change
+916K
Date
Q1 2026
|
JPMorgan Chase & Co | Added· Q1 2026 | – | +916K | – | Q1 2026 | |||||
|
Caligan Partners LP
· New
Change
+878K
Date
Q1 2026
|
Caligan Partners LP | New· Q1 2026 | – | +878K | – | Q1 2026 | |||||
|
Bank of America Corp
· Added
Change
+808K
Date
Q1 2026
|
Bank of America Corp | Added· Q1 2026 | – | +808K | – | Q1 2026 | |||||
|
Perceptive Advisors LLC
· Added
Change
+714K
Date
Q1 2026
|
Perceptive Advisors LLC | Added· Q1 2026 | – | +714K | – | Q1 2026 | |||||
|
Deerfield Management Company, L.P.
· Exited
Change
−711K
Δ Own
−100.0%
Date
Q1 2026
|
Deerfield Management Company, L.P. | Exited· Q1 2026 | – | −711K | −100.0% | Q1 2026 | |||||
|
Braidwell LP
· Reduced
Change
−702K
Date
Q1 2026
|
Braidwell LP | Reduced· Q1 2026 | – | −702K | – | Q1 2026 | |||||
|
Point72 Asset Management, L.P.
· Exited
Change
−662K
Δ Own
−100.0%
Date
Q1 2026
|
Point72 Asset Management, L.P. | Exited· Q1 2026 | – | −662K | −100.0% | Q1 2026 | |||||
|
Paradigm Biocapital Advisors LP
· Added
Change
+490K
Date
Q1 2026
|
Paradigm Biocapital Advisors LP | Added· Q1 2026 | – | +490K | – | Q1 2026 | |||||
|
Commodore Capital LP
· Reduced
Change
−476K
Date
Q1 2026
|
Commodore Capital LP | Reduced· Q1 2026 | – | −476K | – | Q1 2026 | |||||
|
Capital World Investors
· Added
Change
+466K
Date
Q1 2026
|
Capital World Investors | Added· Q1 2026 | – | +466K | – | Q1 2026 | |||||
|
Pictet Asset Management Holding SA
· Reduced
Change
−422K
Date
Q1 2026
|
Pictet Asset Management Holding SA | Reduced· Q1 2026 | – | −422K | – | Q1 2026 | |||||
|
Samlyn Capital, LLC
· New
Change
+397K
Date
Q1 2026
|
Samlyn Capital, LLC | New· Q1 2026 | – | +397K | – | Q1 2026 | |||||
|
State Street
· Added
Change
+344K
Date
Q1 2026
|
State Street | Added· Q1 2026 | – | +344K | – | Q1 2026 | |||||
|
Adar1 Capital Management, LLC
· Added
Change
+304K
Date
Q1 2026
|
Adar1 Capital Management, LLC | Added· Q1 2026 | – | +304K | – | Q1 2026 | |||||
| Insider | Title | Type | Price | Qty | Value | Owned | ΔOwn | Trade date | Filed date | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Burrows Scott L.
· Officer
2 operations
−$658K
|
Burrows Scott L. | Officer | 2 operations | $87.55–$88.37 | −8K | −$658K | 98K | −7.1% | Jul 1, 2026 | Jul 2, 2026 | |||||||||
|
Burrows Scott L.
· Officer
2 operations
0
|
Burrows Scott L. | Officer | 2 operations | $14.50 | 0 | – | 352K | – | Jul 1, 2026 | Jul 2, 2026 | |||||||||
|
Sloan Sheldon
· Officer
2 operations
−$731K
|
Sloan Sheldon | Officer | 2 operations | $87.52–$88.34 | −8K | −$731K | 0 | −100.0% | Jul 1, 2026 | Jul 2, 2026 | |||||||||
|
Sloan Sheldon
· Officer
2 operations
0
|
Sloan Sheldon | Officer | 2 operations | $27.46 | 0 | – | 305K | – | Jul 1, 2026 | Jul 2, 2026 | |||||||||
|
Turtle Cameron
· Director
3 operations
−$1.3M
|
Turtle Cameron | Director | 3 operations | $87.44–$88.91 | −15K | −$1.3M | 583K | −2.5% | Jul 1, 2026 | Jul 2, 2026 | |||||||||
|
Burrows Scott L.
· Officer
2 operations
−$1.3M
|
Burrows Scott L. | Officer | 2 operations | $87.12–$87.14 | −15K | −$1.3M | 98K | −13.3% | Jun 25, 2026 | Jun 26, 2026 | |||||||||
|
Burrows Scott L.
· Officer
2 operations
0
|
Burrows Scott L. | Officer | 2 operations | $14.50 | 0 | – | 360K | – | Jun 25, 2026 | Jun 26, 2026 | |||||||||
|
Fairmount Funds Management LLC
· Director
Sell
−$400M
|
Fairmount Funds Management LLC | Director | Sell | $85.31 | −4.7M | −$400M | 0 | −100.0% | Jun 23, 2026 | Jun 23, 2026 | |||||||||
|
Fairmount Funds Management LLC
· Director
2 operations
650K
|
Fairmount Funds Management LLC | Director | 2 operations | – | 650K | – | 0 | – | Jun 23, 2026 | Jun 23, 2026 | |||||||||
|
Henderson Michael Thomas
· Director
Sell
−$2.0M
|
Henderson Michael Thomas | Director | Sell | $100.00 | −20K | −$2.0M | 69K | −22.6% | Jun 22, 2026 | Jun 23, 2026 | |||||||||
|
Sloan Sheldon
· Officer
Sell
−$625K
|
Sloan Sheldon | Officer | Sell | $75.00 | −8K | −$625K | 0 | – | Jun 3, 2026 | Jun 3, 2026 | |||||||||
|
Sloan Sheldon
· Officer
2 operations
0
|
Sloan Sheldon | Officer | 2 operations | $27.46 | 0 | – | 313K | – | Jun 3, 2026 | Jun 3, 2026 | |||||||||
|
Turtle Cameron
· Director
3 operations
−$1.1M
|
Turtle Cameron | Director | 3 operations | $69.40–$71.38 | −15K | −$1.1M | 598K | – | Jun 1, 2026 | Jun 3, 2026 | |||||||||
|
Burrows Scott L.
· CFO
3 operations
−$533K
|
Burrows Scott L. | CFO | 3 operations | $69.75–$72.06 | −8K | −$533K | 98K | – | Jun 1, 2026 | Jun 3, 2026 | |||||||||
|
Burrows Scott L.
· CFO
2 operations
0
|
Burrows Scott L. | CFO | 2 operations | $14.50 | 0 | – | 375K | – | Jun 1, 2026 | Jun 3, 2026 | |||||||||
N
A
M
G
A
A
175 reporting institutions disclosed SYRE position changes in the Q1 2026 snapshot.
For each manager, WhoBought compares accepted consecutive 13F share counts. Share change is current shares minus prior shares. Estimated dollar change is that signed share change multiplied by the split-adjusted quarter-mean close. The activity table on this page uses Q1 2026.
An investor crossing 5% of a share class generally files Schedule 13D for activist intent or Schedule 13G for a passive position. The technical form names appear here rather than in the activity rows.
Ownership and institutional activity come from SEC Form 13F filings. Insider activity comes from SEC Form 4, and large-shareholder activity from SEC Schedules 13D and 13G. FMP supplies price data only. Company logos use the local verified Parqet cache with one shared fallback.
Form 13F is a quarterly disclosure and is normally filed after the quarter ends. Every ownership and activity value therefore names its represented period; it is not presented as a live position.
A muted dash marks a missing table value. It means the filing omitted the value, comparable data is unavailable, or no prior position exists for comparison.