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Karyopharm Therapeutics Inc. (KPTI) institutional ownership

Latest close $7.87 Jul 21, 2026
Market cap$56M 52-week range SectorHealthcare
Funds holding · Q1 2026
79
reported KPTI position changes
Top owners · Q1 2026
No disclosed owners are available.
Institutional activity · Q1 2026
Activity unavailable N/A
55 buyers · 24 sellers

Karyopharm Therapeutics Inc. (KPTI) price and institutional activity

Dates

Q1 2026

$0 bought by 55 investors
Commodore Capital LPRa Capital Management, L.P. +53 more
$0 sold by 24 investors
Opaleye Management Inc.Affinity Asset Advisors, LLC +22 more
Bought Sold Totals per quarter; hover a bar for the names.

Karyopharm Therapeutics Inc. (KPTI) institutional activity · 79

Investor Type Est. change Change Δ Own Date
Commodore Capital LP · New
Change +1.9M Date Q1 2026
Commodore Capital LP New· Q1 2026 +1.9M Q1 2026
Ra Capital Management, L.P. · New
Change +1.9M Date Q1 2026
Ra Capital Management, L.P. New· Q1 2026 +1.9M Q1 2026
Adage Capital Partners Gp, L.L.C. · Added
Change +1.4M Date Q1 2026
Adage Capital Partners Gp, L.L.C. Added· Q1 2026 +1.4M Q1 2026
Goldman Sachs Group Inc · New
Change +948K Date Q1 2026
Goldman Sachs Group Inc New· Q1 2026 +948K Q1 2026
Opaleye Management Inc. · Exited
Change −930K Δ Own −100.0% Date Q1 2026
Opaleye Management Inc. Exited· Q1 2026 −930K −100.0% Q1 2026
Catalio Capital Management, LP · Added
Change +755K Date Q1 2026
Catalio Capital Management, LP Added· Q1 2026 +755K Q1 2026
Millennium Management LLC · New
Change +421K Date Q1 2026
Millennium Management LLC New· Q1 2026 +421K Q1 2026
Affinity Asset Advisors, LLC · Reduced
Change −390K Date Q1 2026
Affinity Asset Advisors, LLC Reduced· Q1 2026 −390K Q1 2026
Avidity Partners Management LP · Added
Change +329K Date Q1 2026
Avidity Partners Management LP Added· Q1 2026 +329K Q1 2026
Braidwell LP · Exited
Change −303K Δ Own −100.0% Date Q1 2026
Braidwell LP Exited· Q1 2026 −303K −100.0% Q1 2026
Vanguard · Added
Change +303K Date Q1 2026
Vanguard Added· Q1 2026 +303K Q1 2026
Exome Asset Management LLC · Exited
Change −296K Δ Own −100.0% Date Q1 2026
Exome Asset Management LLC Exited· Q1 2026 −296K −100.0% Q1 2026
Acorn Capital Advisors, LLC · New
Change +288K Date Q1 2026
Acorn Capital Advisors, LLC New· Q1 2026 +288K Q1 2026
Ameriprise Financial Inc · Exited
Change −277K Δ Own −100.0% Date Q1 2026
Ameriprise Financial Inc Exited· Q1 2026 −277K −100.0% Q1 2026
Eversept Partners, LP · New
Change +276K Date Q1 2026
Eversept Partners, LP New· Q1 2026 +276K Q1 2026
Data through Q1 2026 · filed May 28, 2026
15 of 79

Famous investor activity in Karyopharm Therapeutics Inc. (KPTI)

Karyopharm Therapeutics Inc. (KPTI) insider trading

Company insiders, action and economics first; trade and filed dates last.
Dates
Insider Title Type Price Qty Value Owned ΔOwn Trade date Filed date
Oliger Christy J. · Director Grant (A) 16K
Owned 16K Trade date May 21, 2026 Filed date May 26, 2026
Oliger Christy J. Director Grant (A) 16K 16K May 21, 2026 May 26, 2026
Pakianathan Deepika · Director Grant (A) 16K
Owned 16K Trade date May 21, 2026 Filed date May 26, 2026
Pakianathan Deepika Director Grant (A) 16K 16K May 21, 2026 May 26, 2026
Schor Chen · Director Grant (A) 16K
Owned 16K Trade date May 21, 2026 Filed date May 26, 2026
Schor Chen Director Grant (A) 16K 16K May 21, 2026 May 26, 2026
Su Zhen · Director Grant (A) 16K
Owned 16K Trade date May 21, 2026 Filed date May 26, 2026
Su Zhen Director Grant (A) 16K 16K May 21, 2026 May 26, 2026
Bohlin Garen G. · Director Grant (A) 16K
Owned 19K Trade date May 21, 2026 Filed date May 26, 2026
Bohlin Garen G. Director Grant (A) 16K 19K May 21, 2026 May 26, 2026
Greene Barry E. · Director Grant (A) 16K
Owned 16K Trade date May 21, 2026 Filed date May 26, 2026
Greene Barry E. Director Grant (A) 16K 16K May 21, 2026 May 26, 2026
Poulton Stuart · Officer Sell −$4K
Price $9.50 Qty −403 Owned 95K Trade date May 14, 2026 Filed date May 15, 2026
Poulton Stuart Officer Sell $9.50 −403 −$4K 95K May 14, 2026 May 15, 2026
Rangwala Reshma · Officer Sell −$4K
Price $9.50 Qty −408 Owned 57K Trade date May 14, 2026 Filed date May 15, 2026
Rangwala Reshma Officer Sell $9.50 −408 −$4K 57K May 14, 2026 May 15, 2026
Cheng Sohanya Roshan · Officer Sell −$3K
Price $9.50 Qty −324 Owned 108K Trade date May 14, 2026 Filed date May 15, 2026
Cheng Sohanya Roshan Officer Sell $9.50 −324 −$3K 108K May 14, 2026 May 15, 2026
Abate Kristin · Officer Sell −$504
Price $9.50 Qty −53 Owned 24K Trade date May 14, 2026 Filed date May 15, 2026
Abate Kristin Officer Sell $9.50 −53 −$504 24K May 14, 2026 May 15, 2026
Paulson Richard A. · Director Sell −$21K
Price $9.50 Qty −2K Owned 270K Trade date May 14, 2026 Filed date May 15, 2026
Paulson Richard A. Director Sell $9.50 −2K −$21K 270K May 14, 2026 May 15, 2026
Mano Michael · Officer Sell −$3K
Price $9.50 Qty −266 Owned 94K Trade date May 14, 2026 Filed date May 15, 2026
Mano Michael Officer Sell $9.50 −266 −$3K 94K May 14, 2026 May 15, 2026
Poulton Stuart · Officer Grant (A) 896
Owned 95K Trade date May 13, 2026 Filed date May 15, 2026
Poulton Stuart Officer Grant (A) 896 95K May 13, 2026 May 15, 2026
Rangwala Reshma · Officer Grant (A) 947
Owned 57K Trade date May 13, 2026 Filed date May 15, 2026
Rangwala Reshma Officer Grant (A) 947 57K May 13, 2026 May 15, 2026
Cheng Sohanya Roshan · Officer Grant (A) 947
Owned 108K Trade date May 13, 2026 Filed date May 15, 2026
Cheng Sohanya Roshan Officer Grant (A) 947 108K May 13, 2026 May 15, 2026
15 of 57
15 of 57 Sign in to continue to older insider transactions.

Karyopharm Therapeutics Inc. (KPTI) activist and large shareholders

Dates
Owner/Filer identity Shares reported % of shares outstanding Filing date
Avidity Partners Management LP 11.2M
% of shares outstanding 9.5% Filing date Feb 14, 2024
Avidity Partners Management LP 11.2M 9.5% Feb 14, 2024
Affinity Asset Advisors, LLC 2.1M
% of shares outstanding 8.6% Filing date May 14, 2026
Affinity Asset Advisors, LLC 2.1M 8.6% May 14, 2026
Adage Capital Management, L.P. 1.8M
% of shares outstanding 8.1% Filing date May 13, 2026
Adage Capital Management, L.P. 1.8M 8.1% May 13, 2026
T. Rowe Price Investment Management, Inc. 1.5M
% of shares outstanding 6.6% Filing date Jun 5, 2026
T. Rowe Price Investment Management, Inc. 1.5M 6.6% Jun 5, 2026
Integrated Core Strategies (us) LLC 998K
% of shares outstanding 5.4% Filing date Feb 10, 2026
Integrated Core Strategies (us) LLC 998K 5.4% Feb 10, 2026
The Goldman Sachs Group, Inc. 991K
% of shares outstanding 5.1% Filing date May 12, 2026
The Goldman Sachs Group, Inc. 991K 5.1% May 12, 2026
J. Wood Capital Advisors LLC 1.0M
% of shares outstanding 5.0% Filing date Nov 3, 2025
J. Wood Capital Advisors LLC 1.0M 5.0% Nov 3, 2025
Highbridge Capital Management, LLC 650K
% of shares outstanding 4.9% Filing date Nov 14, 2025
Highbridge Capital Management, LLC 650K 4.9% Nov 14, 2025
8 of 18

Karyopharm Therapeutics Inc. (KPTI) ownership FAQ

Who owns KPTI?

79 reporting institutions disclosed KPTI position changes in the Q1 2026 snapshot.

How is institutional activity calculated?

For each manager, WhoBought compares accepted consecutive 13F share counts. Share change is current shares minus prior shares. Estimated dollar change is that signed share change multiplied by the split-adjusted quarter-mean close. The activity table on this page uses Q1 2026.

What are activist and large shareholder filings?

An investor crossing 5% of a share class generally files Schedule 13D for activist intent or Schedule 13G for a passive position. The technical form names appear here rather than in the activity rows.

Where does this data come from?

Ownership and institutional activity come from SEC Form 13F filings. Insider activity comes from SEC Form 4, and large-shareholder activity from SEC Schedules 13D and 13G. FMP supplies price data only. Company logos use the local verified Parqet cache with one shared fallback.

Why are ownership reports delayed?

Form 13F is a quarterly disclosure and is normally filed after the quarter ends. Every ownership and activity value therefore names its represented period; it is not presented as a live position.

How are missing table values shown?

A muted dash marks a missing table value. It means the filing omitted the value, comparable data is unavailable, or no prior position exists for comparison.