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Ionis Pharmaceuticals, Inc. (IONS) institutional ownership

Latest close $55.87 Jul 23, 2026
Market cap$13.5B 52-week range SectorHealthcare
Funds holding · Q1 2026
460
reported IONS position changes
Top owners · Q1 2026
No disclosed owners are available.
Institutional activity · Q1 2026
Net bought $157M
241 buyers · 219 sellers

Ionis Pharmaceuticals, Inc. (IONS) price and institutional activity

Dates

Q1 2026

$1.7B bought by 241 investors
Capital World Investors$255MTwo Sigma Investments, LP$252M +239 more
$1.5B sold by 219 investors
Two Sigma Advisers, LP-$241MBellevue Group AG-$235M +217 more
Bought Sold Totals per quarter; hover a bar for the names.

Ionis Pharmaceuticals, Inc. (IONS) institutional activity · 460

Investor Type Est. change Change Δ Own Date
Capital World Investors · Added +$255M
Change +3.2M Date Q1 2026
Capital World Investors Added· Q1 2026 +$255M +3.2M Q1 2026
Two Sigma Investments, LP · Added +$252M
Change +3.2M Δ Own +120.3% Date Q1 2026
Two Sigma Investments, LP Added· Q1 2026 +$252M +3.2M +120.3% Q1 2026
Two Sigma Advisers, LP · Exited −$241M
Change −3.1M Δ Own −100.0% Date Q1 2026
Two Sigma Advisers, LP Exited· Q1 2026 −$241M −3.1M −100.0% Q1 2026
Bellevue Group AG · Reduced −$235M
Change −3.0M Date Q1 2026
Bellevue Group AG Reduced· Q1 2026 −$235M −3.0M Q1 2026
T. Rowe Price Investment Management, Inc. · Reduced −$233M
Change −2.9M Date Q1 2026
T. Rowe Price Investment Management, Inc. Reduced· Q1 2026 −$233M −2.9M Q1 2026
Royal Bank of Canada · Added +$212M
Change +2.7M Date Q1 2026
Royal Bank of Canada Added· Q1 2026 +$212M +2.7M Q1 2026
Citadel Advisors LLC Reduced· Q1 2026 −$94M −1.2M −55.8% Q1 2026
Millennium Management LLC · Added +$76M
Change +958K Date Q1 2026
Millennium Management LLC Added· Q1 2026 +$76M +958K Q1 2026
Artisan Partners Limited Partnership · Added +$69M
Change +877K Date Q1 2026
Artisan Partners Limited Partnership Added· Q1 2026 +$69M +877K Q1 2026
Goldman Sachs Group Inc · Added +$67M
Change +844K Date Q1 2026
Goldman Sachs Group Inc Added· Q1 2026 +$67M +844K Q1 2026
Geode · Added +$66M
Change +835K Date Q1 2026
Geode Added· Q1 2026 +$66M +835K Q1 2026
Nomura Holdings Inc · Reduced −$58M
Change −735K Date Q1 2026
Nomura Holdings Inc Reduced· Q1 2026 −$58M −735K Q1 2026
Tri Locum Partners LP · Exited −$44M
Change −557K Δ Own −100.0% Date Q1 2026
Tri Locum Partners LP Exited· Q1 2026 −$44M −557K −100.0% Q1 2026
Barclays PLC · Reduced −$44M
Change −553K Date Q1 2026
Barclays PLC Reduced· Q1 2026 −$44M −553K Q1 2026
Perceptive Advisors LLC · New +$40M
Change +504K Date Q1 2026
Perceptive Advisors LLC New· Q1 2026 +$40M +504K Q1 2026
Data through Q1 2026 · filed Jun 3, 2026
15 of 460

Famous investor activity in Ionis Pharmaceuticals, Inc. (IONS)

Ionis Pharmaceuticals, Inc. (IONS) insider trading

Company insiders, action and economics first; trade and filed dates last.
Dates
Insider Title Type Price Qty Value Owned ΔOwn Trade date Filed date
Reikes Peter N. · Director Grant (A) 3K
Owned 3K Trade date Jul 15, 2026 Filed date Jul 17, 2026
Reikes Peter N. Director Grant (A) 3K 3K Jul 15, 2026 Jul 17, 2026
Hantson Ludwig · Director Grant (A) 3K
Owned 3K Trade date Jul 15, 2026 Filed date Jul 17, 2026
Hantson Ludwig Director Grant (A) 3K 3K Jul 15, 2026 Jul 17, 2026
Herman Joan E. · Director 2 operations 0
Owned 2K Trade date Jul 15, 2026 Filed date Jul 17, 2026
Herman Joan E. Director 2 operations 0 2K Jul 15, 2026 Jul 17, 2026
Berthelsen Spencer R. · Director 2 operations 0
Owned 2K Trade date Jul 15, 2026 Filed date Jul 17, 2026
Berthelsen Spencer R. Director 2 operations 0 2K Jul 15, 2026 Jul 17, 2026
Bennett C. Frank · Officer 2 operations −$1.7M
Price $83.58–$85.46 Qty −21K Owned 0 Trade date Jul 7, 2026 Filed date Jul 9, 2026
Bennett C. Frank Officer 2 operations $83.58–$85.46 −21K −$1.7M 0 Jul 7, 2026 Jul 9, 2026
Bennett C. Frank · Officer 2 operations 0
Owned 12K Trade date Jul 7, 2026 Filed date Jul 9, 2026
Bennett C. Frank Officer 2 operations 0 12K Jul 7, 2026 Jul 9, 2026
Diaz Allene M. · Director Sell −$864K
Price $85.42 Qty −10K Owned 4K ΔOwn −72.6% Trade date Jul 7, 2026 Filed date Jul 9, 2026
Diaz Allene M. Director Sell $85.42 −10K −$864K 4K −72.6% Jul 7, 2026 Jul 9, 2026
Diaz Allene M. · Director 2 operations 0
Price $47.11 Owned 0 Trade date Jul 7, 2026 Filed date Jul 9, 2026
Diaz Allene M. Director 2 operations $47.11 0 0 Jul 7, 2026 Jul 9, 2026
Kordasiewicz Holly B. · Officer Sell −$31K
Price $84.30 Qty −362 Owned 22K ΔOwn −1.6% Trade date Jul 7, 2026 Filed date Jul 9, 2026
Kordasiewicz Holly B. Officer Sell $84.30 −362 −$31K 22K −1.6% Jul 7, 2026 Jul 9, 2026
Yang Michael J. · Director 2 operations 8K
Owned 9K Trade date Jul 1, 2026 Filed date Jul 6, 2026
Yang Michael J. Director 2 operations 8K 9K Jul 1, 2026 Jul 6, 2026
Loscalzo Joseph · Director 2 operations 8K
Owned 8K Trade date Jul 1, 2026 Filed date Jul 6, 2026
Loscalzo Joseph Director 2 operations 8K 8K Jul 1, 2026 Jul 6, 2026
Herman Joan E. · Director 2 operations 8K
Owned 8K Trade date Jul 1, 2026 Filed date Jul 6, 2026
Herman Joan E. Director 2 operations 8K 8K Jul 1, 2026 Jul 6, 2026
Klein Joseph III · Director 2 operations −$910K
Price $79.04–$79.45 Qty −12K Owned 11K ΔOwn −51.1% Trade date Jul 1, 2026 Filed date Jul 6, 2026
Klein Joseph III Director 2 operations $79.04–$79.45 −12K −$910K 11K −51.1% Jul 1, 2026 Jul 6, 2026
Klein Joseph III · Director 2 operations 0
Price $39.94 Owned 0 Trade date Jul 1, 2026 Filed date Jul 6, 2026
Klein Joseph III Director 2 operations $39.94 0 0 Jul 1, 2026 Jul 6, 2026
Klein Joseph III · Director 2 operations 8K
Owned 16K Trade date Jul 1, 2026 Filed date Jul 6, 2026
Klein Joseph III Director 2 operations 8K 16K Jul 1, 2026 Jul 6, 2026
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15 of 87 Sign in to continue to older insider transactions.

Ionis Pharmaceuticals, Inc. (IONS) activist and large shareholders

Dates
Owner/Filer identity Shares reported % of shares outstanding Filing date
FMR LLC 21.5M
% of shares outstanding 15.0% Filing date Feb 9, 2024
FMR LLC 21.5M 15.0% Feb 9, 2024
Capital World Investors 21.2M
% of shares outstanding 12.8% Filing date May 14, 2026
Capital World Investors 21.2M 12.8% May 14, 2026
Vanguard Group Inc 14.2M
% of shares outstanding 9.9% Filing date Feb 13, 2024
Vanguard Group Inc 14.2M 9.9% Feb 13, 2024
BlackRock Inc. 9.1M
% of shares outstanding 6.3% Filing date Jan 26, 2024
BlackRock Inc. 9.1M 6.3% Jan 26, 2024
Wellington Management Group LLP 9.1M
% of shares outstanding 5.8% Filing date Nov 8, 2024
Wellington Management Group LLP 9.1M 5.8% Nov 8, 2024
Vanguard Capital Management 8.3M
% of shares outstanding 5.0% Filing date Apr 30, 2026
Vanguard Capital Management 8.3M 5.0% Apr 30, 2026
Ark Investment Management LLC 7.1M
% of shares outstanding 5.0% Filing date Feb 9, 2022
Ark Investment Management LLC 7.1M 5.0% Feb 9, 2022
Bb Biotech AG 7.8M
% of shares outstanding 5.0% Filing date Nov 14, 2024
Bb Biotech AG 7.8M 5.0% Nov 14, 2024
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Ionis Pharmaceuticals, Inc. (IONS) ownership FAQ

Who owns IONS?

460 reporting institutions disclosed IONS position changes in the Q1 2026 snapshot.

How is institutional activity calculated?

For each manager, WhoBought compares accepted consecutive 13F share counts. Share change is current shares minus prior shares. Estimated dollar change is that signed share change multiplied by the split-adjusted quarter-mean close. The activity table on this page uses Q1 2026.

What are activist and large shareholder filings?

An investor crossing 5% of a share class generally files Schedule 13D for activist intent or Schedule 13G for a passive position. The technical form names appear here rather than in the activity rows.

Where does this data come from?

Ownership and institutional activity come from SEC Form 13F filings. Insider activity comes from SEC Form 4, and large-shareholder activity from SEC Schedules 13D and 13G. FMP supplies price data only. Company logos use the local verified Parqet cache with one shared fallback.

Why are ownership reports delayed?

Form 13F is a quarterly disclosure and is normally filed after the quarter ends. Every ownership and activity value therefore names its represented period; it is not presented as a live position.

How are missing table values shown?

A muted dash marks a missing table value. It means the filing omitted the value, comparable data is unavailable, or no prior position exists for comparison.