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Amylyx Pharmaceuticals, Inc. (AMLX) institutional ownership

Latest close $17.70 Jul 22, 2026
Market cap$688M 52-week range SectorHealthcare
Funds holding · Q1 2026
171
reported AMLX position changes
Top owners · Q1 2026
No disclosed owners are available.
Institutional activity · Q1 2026
Activity unavailable N/A
81 buyers · 90 sellers

Amylyx Pharmaceuticals, Inc. (AMLX) price and institutional activity

Dates

Q1 2026

$0 bought by 81 investors
Jones Hill Capital LPSiren, L.L.C. +79 more
$0 sold by 90 investors
Sofinnova Investments, Inc.Silverarc Capital Management, LLC +88 more
Bought Sold Totals per quarter; hover a bar for the names.

Amylyx Pharmaceuticals, Inc. (AMLX) institutional activity · 171

Investor Type Est. change Change Δ Own Date
Jones Hill Capital LP · New
Change +1.6M Date Q1 2026
Jones Hill Capital LP New· Q1 2026 +1.6M Q1 2026
Siren, L.L.C. · New
Change +1.2M Date Q1 2026
Siren, L.L.C. New· Q1 2026 +1.2M Q1 2026
Adage Capital Partners Gp, L.L.C. · Added
Change +784K Date Q1 2026
Adage Capital Partners Gp, L.L.C. Added· Q1 2026 +784K Q1 2026
Barclays PLC · Added
Change +677K Date Q1 2026
Barclays PLC Added· Q1 2026 +677K Q1 2026
Jupiter Asset Management Ltd · Added
Change +577K Date Q1 2026
Jupiter Asset Management Ltd Added· Q1 2026 +577K Q1 2026
Sofinnova Investments, Inc. · Exited
Change −527K Δ Own −100.0% Date Q1 2026
Sofinnova Investments, Inc. Exited· Q1 2026 −527K −100.0% Q1 2026
Janus Henderson Group PLC · Added
Change +520K Date Q1 2026
Janus Henderson Group PLC Added· Q1 2026 +520K Q1 2026
Silverarc Capital Management, LLC · Exited
Change −506K Δ Own −100.0% Date Q1 2026
Silverarc Capital Management, LLC Exited· Q1 2026 −506K −100.0% Q1 2026
Ameriprise Financial Inc · Exited
Change −502K Δ Own −100.0% Date Q1 2026
Ameriprise Financial Inc Exited· Q1 2026 −502K −100.0% Q1 2026
Patient Square Capital LP · Exited
Change −350K Δ Own −100.0% Date Q1 2026
Patient Square Capital LP Exited· Q1 2026 −350K −100.0% Q1 2026
Two Sigma Advisers, LP · Exited
Change −328K Δ Own −100.0% Date Q1 2026
Two Sigma Advisers, LP Exited· Q1 2026 −328K −100.0% Q1 2026
Ia Global Asset Management Inc. · New
Change +305K Date Q1 2026
Ia Global Asset Management Inc. New· Q1 2026 +305K Q1 2026
Nantahala Capital Management, LLC · Reduced
Change −300K Date Q1 2026
Nantahala Capital Management, LLC Reduced· Q1 2026 −300K Q1 2026
State Street · Added
Change +293K Date Q1 2026
State Street Added· Q1 2026 +293K Q1 2026
Qube Research & Technologies Ltd · Added
Change +289K Date Q1 2026
Qube Research & Technologies Ltd Added· Q1 2026 +289K Q1 2026
Data through Q1 2026 · filed Jun 4, 2026
15 of 171

Famous investor activity in Amylyx Pharmaceuticals, Inc. (AMLX)

Amylyx Pharmaceuticals, Inc. (AMLX) insider trading

Company insiders, action and economics first; trade and filed dates last.
Dates
Insider Title Type Price Qty Value Owned ΔOwn Trade date Filed date
Mazzariello Gina · Officer Sell −$264K
Price $17.61 Qty −15K Owned 179K ΔOwn −7.7% Trade date Jul 10, 2026 Filed date Jul 13, 2026
Mazzariello Gina Officer Sell $17.61 −15K −$264K 179K −7.7% Jul 10, 2026 Jul 13, 2026
Mazzariello Gina · Officer Sell −$275K
Price $18.32 Qty −15K Owned 194K ΔOwn −7.2% Trade date Jul 9, 2026 Filed date Jul 13, 2026
Mazzariello Gina Officer Sell $18.32 −15K −$275K 194K −7.2% Jul 9, 2026 Jul 13, 2026
Zeiher Bernhardt G. · Director Grant (A) 24K
Owned 24K Trade date Jun 4, 2026 Filed date Jun 8, 2026
Zeiher Bernhardt G. Director Grant (A) 24K 24K Jun 4, 2026 Jun 8, 2026
Firestone Karen · Director Grant (A) 24K
Owned 24K Trade date Jun 4, 2026 Filed date Jun 8, 2026
Firestone Karen Director Grant (A) 24K 24K Jun 4, 2026 Jun 8, 2026
Quimi Daphne · Director Grant (A) 24K
Owned 24K Trade date Jun 4, 2026 Filed date Jun 8, 2026
Quimi Daphne Director Grant (A) 24K 24K Jun 4, 2026 Jun 8, 2026
Milne George M. Jr · Director Grant (A) 24K
Owned 24K Trade date Jun 4, 2026 Filed date Jun 8, 2026
Milne George M. Jr Director Grant (A) 24K 24K Jun 4, 2026 Jun 8, 2026
Fonteyne Paul R. · Director Grant (A) 24K
Owned 24K Trade date Jun 4, 2026 Filed date Jun 8, 2026
Fonteyne Paul R. Director Grant (A) 24K 24K Jun 4, 2026 Jun 8, 2026
Firestone Karen · Director Buy +$51K
Price $13.51 Qty +4K Owned 67K Trade date May 21, 2026 Filed date May 26, 2026
Firestone Karen Director Buy $13.51 +4K +$51K 67K May 21, 2026 May 26, 2026
Cohen Joshua B. · Director 2 operations 622K
Owned 373K Trade date Mar 5, 2026 Filed date Mar 9, 2026
Cohen Joshua B. Director 2 operations 622K 373K Mar 5, 2026 Mar 9, 2026
Mazzariello Gina · Officer 2 operations 187K
Owned 112K Trade date Mar 5, 2026 Filed date Mar 9, 2026
Mazzariello Gina Officer 2 operations 187K 112K Mar 5, 2026 Mar 9, 2026
Frates James M. · Officer 2 operations 240K
Owned 144K Trade date Mar 5, 2026 Filed date Mar 9, 2026
Frates James M. Officer 2 operations 240K 144K Mar 5, 2026 Mar 9, 2026
Klee Justin B. · Director, Officer 2 operations 622K
Owned 373K Trade date Mar 5, 2026 Filed date Mar 9, 2026
Klee Justin B. Director, Officer 2 operations 622K 373K Mar 5, 2026 Mar 9, 2026
Bedrosian Camille L. · Officer 2 operations 240K
Owned 144K Trade date Mar 5, 2026 Filed date Mar 9, 2026
Bedrosian Camille L. Officer 2 operations 240K 144K Mar 5, 2026 Mar 9, 2026
Klee Justin B. · Director, Officer Sell −$424K
Price $14.47 Qty −29K Owned 3.3M Trade date Mar 2, 2026 Filed date Mar 4, 2026
Klee Justin B. Director, Officer Sell $14.47 −29K −$424K 3.3M Mar 2, 2026 Mar 4, 2026
Cohen Joshua B. · Director, Officer Sell −$424K
Price $14.48 Qty −29K Owned 3.3M Trade date Mar 2, 2026 Filed date Mar 4, 2026
Cohen Joshua B. Director, Officer Sell $14.48 −29K −$424K 3.3M Mar 2, 2026 Mar 4, 2026
15 of 44
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Amylyx Pharmaceuticals, Inc. (AMLX) activist and large shareholders

Dates
Owner/Filer identity Shares reported % of shares outstanding Filing date
Perceptive Advisors LLC 8.3M
% of shares outstanding 7.5% Filing date May 15, 2026
Perceptive Advisors LLC 8.3M 7.5% May 15, 2026
Tcg Crossover Gp Ii, LLC 4.6M
% of shares outstanding 6.8% Filing date Aug 26, 2024
Tcg Crossover Gp Ii, LLC 4.6M 6.8% Aug 26, 2024
Perceptive Advisors LLC 4.5M
% of shares outstanding 6.5% Filing date Oct 25, 2024
Perceptive Advisors LLC 4.5M 6.5% Oct 25, 2024
Panacea Innovation Ltd 4.2M
% of shares outstanding 6.2% Filing date Mar 11, 2024
Panacea Innovation Ltd 4.2M 6.2% Mar 11, 2024
Goldman Sachs Group Inc 3.7M
% of shares outstanding 5.4% Filing date Jun 9, 2023
Goldman Sachs Group Inc 3.7M 5.4% Jun 9, 2023
Vanguard Group Inc 3.1M
% of shares outstanding 4.5% Filing date Nov 12, 2024
Vanguard Group Inc 3.1M 4.5% Nov 12, 2024
Viking Global Investors LP 3.0M
% of shares outstanding 4.4% Filing date Feb 14, 2024
Viking Global Investors LP 3.0M 4.4% Feb 14, 2024
Point72 Asset Management, L.P. 2.8M
% of shares outstanding 4.1% Filing date Feb 14, 2024
Point72 Asset Management, L.P. 2.8M 4.1% Feb 14, 2024
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Amylyx Pharmaceuticals, Inc. (AMLX) ownership FAQ

Who owns AMLX?

171 reporting institutions disclosed AMLX position changes in the Q1 2026 snapshot.

How is institutional activity calculated?

For each manager, WhoBought compares accepted consecutive 13F share counts. Share change is current shares minus prior shares. Estimated dollar change is that signed share change multiplied by the split-adjusted quarter-mean close. The activity table on this page uses Q1 2026.

What are activist and large shareholder filings?

An investor crossing 5% of a share class generally files Schedule 13D for activist intent or Schedule 13G for a passive position. The technical form names appear here rather than in the activity rows.

Where does this data come from?

Ownership and institutional activity come from SEC Form 13F filings. Insider activity comes from SEC Form 4, and large-shareholder activity from SEC Schedules 13D and 13G. FMP supplies price data only. Company logos use the local verified Parqet cache with one shared fallback.

Why are ownership reports delayed?

Form 13F is a quarterly disclosure and is normally filed after the quarter ends. Every ownership and activity value therefore names its represented period; it is not presented as a live position.

How are missing table values shown?

A muted dash marks a missing table value. It means the filing omitted the value, comparable data is unavailable, or no prior position exists for comparison.